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METHADONE MAINTENANCE TREATMENT
Pharmacokinetics, Psychopathology and
Craving
©1997 Dr Jan
Willem de Vos
Summary
Chapter 1
Introduction Aims
of the present study
Chapter 2
Pharmacokinetics of methadone and
its primary metabolite in twenty heroin-dependent subjects
Chapter 3
Determination and pharmacokinetics of dextromoramide in methadone
maintenace treatment
Chapter 4
Patterns of craving and pharmacokinetics in long-term
heroin-dependent subjects in methadone maintenance treatment
Chapter 5
Craving despite extremely high
methadone dosage
Chapter 6
Craving patterns in methadone maintenance treatment with
dextromoramide as adjuvant
Chapter 7
L-methadone and d,l-methadone in methadone maintenance treatment:
a comparison of therapeutic effectiveness
Chapter 8
Opiate craving and and presence of psychopathology
Chapter 9
Concluding remarks and
recommendations for future research
Appendix
Summary
Bibliography
Acknowledgements
1.
Subjective opiate craving symptoms are more related to habitual ingestion
time than to the actual plasma methadone concentration (this Thesis).
2.
The advantage of using racemic methadone in methadone maintenance
treatment over levomethadone is the amount in which it can be prescribed: twice
as much (this Thesis).
3.
Additional
dextromoramide ingestion besides methadone in methadone maintenance treatment,
gives a simultaneous reduction of opiate craving (this Thesis).
This thesis was prepared at the Laboratory of Pharmacology,
head Remy S Leeuwin Ph.D University of Amsterdam, Academic
Medical Centre
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