MODULATORS OF DRUG DEPENDENCE PHENOMENA

Factors Affecting Morphine Withdrawal Syndrome and Cocaine-intake in Rodents

Outline of the studies

Abbreviations

PART 1: Drug Dependence and Harmful Use of Drugs

Chapter 1   Definition of terms and classification of dependence-producing drugs

PART 2: Opioid Dependence

Chapter 2   Opioids

PART 3: Morphine Withdrawal Syndrome - Experimental Studies 

Chapter 3   Excitatory amino acid receptor antagonists and naloxoneprecipitated withdrawal syndrome in morphine-dependent mice 

SLT Cappendijk, R de Vries and MR Dzoljic European Neuropsychopharmacology 3: 111-116,1993

Chapter 4   Inhibitory effect of nitric oxide (NO) synthase inhibitors on naloxone-precipitated withdrawal syndrome in morphinedependent mice  

SLT Cappendijk, R de Vries and MR Dzoljic Neuroscience Letters 162: 97-100, 1993

Chapter 5   Comparative study of normotensive and hypertensive nitric oxide synthase inhibitors on morphine withdrawal syndrome in rats SLT Cappendijk, SY Duval, R de Vries and MR Dzoljic Neuroscience Letters 183: 67-70, 1995

Chapter 6   "Withdrawal substance" in cerebrospinal fluid of morphineabstinent rats 

SLT Cappendijk, J Silberring, R de Vries and MR Dzoljic Submitted for publication, 1994 Short communication: Regulatory Peptides 1: S227-228, 1994

Chapter 7  The inhibitory effect of norharman on morphine withdrawal sydrome in rats - comparison with ibogaine 

SLT Cappendijk, D Fekkes, R de Vries and MR Dzoljic Behavioural Brain Research 65: 117-119, 1994 Short communication: Regulatory Peptides 54: 39-40, 1994 

PART 4: Drug Dependence induced by Psychostimulants

Chapter 8    Psychostimulants

PART 5: Cocaine Dependence - Experimental Study

Chapter 9   Inhibitory effects of ibogaine on cocaine self-administration in rats 

SLT Cappendijk and MR Dzoljic European Journal of Pharmacology 241: 261-265, 1993 

Modulators of drug dependence phenomena

Concluding remarks 

Suggestions for further research