Pharmacokinetics, Psychopathology and Craving

1997 Dr Jan Willem de Vos


Chapter 1
Introduction Aims of the present study

Chapter 2
Pharmacokinetics of methadone and its primary metabolite in twenty heroin-dependent subjects

Chapter 3
Determination and pharmacokinetics of dextromoramide in methadone maintenace treatment

Chapter 4
Patterns of craving and pharmacokinetics in long-term heroin-dependent subjects in methadone maintenance treatment

Chapter 5
Craving despite extremely high methadone dosage

Chapter 6
Craving patterns in methadone maintenance treatment with dextromoramide as adjuvant

Chapter 7
L-methadone and d,l-methadone in methadone maintenance treatment: a comparison of therapeutic effectiveness

Chapter 8
Opiate craving and and presence of psychopathology

Chapter 9
Concluding remarks and recommendations for future research


1. Subjective opiate craving symptoms are more related to habitual ingestion time than to the actual plasma methadone concentration (this Thesis).

2. The advantage of using racemic methadone in methadone maintenance treatment over levomethadone is the amount in which it can be prescribed: twice as much (this Thesis).

3. Additional dextromoramide ingestion besides methadone in methadone maintenance treatment, gives a simultaneous reduction of opiate craving (this Thesis).

This thesis was prepared at the Laboratory of Pharmacology, head Remy S Leeuwin Ph.D University of Amsterdam, Academic Medical Centre